彭怡禎 副教授

副教授
彭怡禎

English
電話:+886-6-275-7575 ext.58123    研究室：58104 or 58114轉61
email: ipeng@mail.ncku.edu.tw
實驗室網頁：彭怡禎老師 實驗室
研究專長：分子代謝醫學、脂質與麩醯胺酸代謝、營養與表觀遺傳調控、癌症生物學。

研究方向：

         癌細胞能透過代謝重整(metabolic reprogramming)適應營養缺乏、氧化壓力及化療等各種壓力，進而促進細胞生長、轉移及產生化療抗藥性。本實驗室致力於探討癌細胞中脂質代謝及麩醯胺酸代謝的重整機制，並進一步解析癌細胞如何藉由表觀遺傳調控(如DNA去甲基化)，及蛋白質O-GlcNAc醣基化修飾，重塑細胞內的代謝途徑，以促進腫瘤惡化及治療抗性。此外，我們結合代謝體學、脂質體學及分子生物學技術，系統性探討癌細胞中脂質代謝重整、油滴形成與功能、脂質相關代謝產物的動態變化，以及代謝訊息傳遞與細胞命運之間的關聯，並尋找具有診斷、預後評估及治療潛力的癌症分子生物標記。本實驗室的研究目標為解析促使癌細胞生長、轉移及產生化療抗藥性的關鍵代謝途徑，釐清其分子調控機制，並發展新型代謝標靶治療策略，以促進抗癌藥物的研發與臨床應用。另一方面，我們亦探討脂質代謝及麩醯胺酸代謝在肝細胞及脂肪細胞中的調控機制，解析其在肥胖、代謝功能異常相關脂肪肝疾病(MASLD)及其他代謝性疾病中的角色，期望針對不同疾病的代謝異常發展創新的預防與治療策略。

 

研究主題：

  1. 探討基因啟動子DNA去甲基化與蛋白質O-GlcNAc醣基化修飾對脂肪酸合成酶(FAS)蛋白表現與穩定性的調控機制，並解析其在代謝功能異常相關脂肪肝疾病(MASLD)肝臟脂肪變性及發炎反應中的角色。
  2. 探討蛋白質O-GlcNAc醣基化修飾調控脂肪酸轉位酶CD36及其介導之脂質代謝重整的功能，並進一步釐清其在肝細胞癌(HCC)化療抗藥性形成中的分子機制。
  3. 探討油滴生成於大腸直腸癌(CRC)化療療效中的功能，並解析其相關的代謝調控機制。

學歷

博士 生物化學與分子生物學所，美國加州大學河濱分校
碩士 農業化學所，國立臺灣大學
學士 農業化學系，國立臺灣大學

經歷

年份 職位 機構
2020 副教授 國立成功大學 生命科學系
2014 助理教授 國立成功大學 生命科學系
2012 博士後研究員 美國紐約石溪大學
2011 博士後研究員 美國加州大學河濱分校

榮譽與獎勵

1. 2025 國立成功大學113學年度生物科學與科技學院 輔導優良導師

2. 2023 國立成功大學111學年度生物科學與科技學院 教學優良導師

3. 2020 國立成功大學108學年度生物科學與科技學院 輔導優良導師

4. 2016-2019 Outstanding Young Research Scholar Project Grants from the Ministry of Science and Technology, R.O.C., Taiwan.

5. 2016 High Quality Paper Awards, Department of Life Sciences, National Cheng Kung University, Taiwan.

6. 2014-2017 Special Outstanding Talents of the Ministry of Science and Technology Awards, Ministry of Science and Technology, R.O.C., Taiwan.

7. 2009 Annual Biochemistry and Molecular Biology Research Symposium Best Poster Award, University of California, Riverside, USA.

代表著作

  1. Zou-Han Lin, Pin-I Chou (co-first author), Jia-Wei Chang, Zong-Chen Lin, Yuan-Ting Sun, Ming-Hui Chang, Shih-En Huang, Yu-Min Yeh, and I-Chen Peng*. (2026 Apr) Promoter demethylation and protein O-GlcNAcylation-mediated enhancement of fatty acid synthase contributes to hepatic steatosis and inflammation in MASLD. The Journal of Nutritional Biochemistry. 150:110227. (* For correspondence)
  2. Yu-Tsen Hsieh, Tung-Hsuan Kang (co-first author), Hsin-Yi Hung, Yi-Han Chang, Kuan-Chen Cheng, Chia-Yih Wang, Wen-Tai Chiu, Pai-Sheng Chen, Shih-Chieh Lin, and I-Chen Peng*. (2025 Jul) Identification of a 2-phenoxychromone derivative as a novel inhibitor of lipid droplet formation in adipocytes and hepatocytes. Results in Chemistry. 16:102389. (* For correspondence)
  3.  Yu-Ying Chao, Ruei-Ci Lin, Ping‑Jui Su, Chu-An Wang, Ting-Yuan Tu, Ya-Chin Hou, Yi-Tzui Tsai, I-Chen Peng, Shaw-Jenq Tsai, Yan-Shen Shan, and Chia-Yih Wang. (2025 Jan) Melanophilin-induced primary cilia promote pancreatic cancer metastasis. Cell Death & Disease. 16(1):22.
  4. Yu-Ying Chao, Bu-Miin Huang, I-Chen Peng, Pei-Rong Lee, Yi-Shyun Lai, Wen-Tai Chiu, Yi-Syuan Lin, Shih-Chieh Lin, Jung-Hsuan Chang, Pai-Sheng Chen, Shaw-Jenq Tsai*, and Chia-Yih Wang*. (2022 Dec) ATM- and ATR-induced primary ciliogenesis promotes cisplatin resistance in pancreatic ductal adenocarcinoma. Journal of Cellular Physiology. 237(12):4487-4503.
  5. Jin-Wei Jhu, Jia-Bao Yan, Zou-Han Lin, Shih-Chieh Lin, and I-Chen Peng*. (2021 Sep). SREBP1-induced glutamine synthetase triggers a feedforward loop to upregulate SREBP1 through Sp1 O-GlcNAcylation and augments lipid droplet formation in cancer cells. International Journal of Molecular Sciences.22(18), 9814. (* for correspondence)
  6. Jia-Bao Yan, Chien-Cheng Lai, Jin-Wei Jhu,Brendan Gongol, Traci L. Marin, Shih-Chieh Lin, Hsiang-Yi Chiu, Chia-Jui Yen, Liang-Yi Wang, and I-Chen Peng*. (2020 Jun) Insulin and metformin control cell proliferation by regulating TDG-mediated DNA demethylation in liver and breast cancer cells. Molecular Therapy-Oncolytics. 18: 282-294. (* for correspondence)
  7. Pai-Sheng Chen, Wen-Tai Chiu, Pei-Ling Hsu, Shih-Chieh Lin , I-Chen Peng, Chia-Yih Wang , and Shaw-Jenq Tsai. (2020 May) Pathophysiological implications of hypoxia in human diseases. Journal of Biomedical Science. 27(1):63.
  8. I-Chen Peng*, Alex J. Bott, and Wei-Xing Zong*. (2016 Oct) Spectrophotometric determination of glutamine synthetase activity in cultured cells. Bio-protocol 6(19): e1959. (* for correspondence)
  9. Alex J. Bott*, I-Chen Peng* (co-first author), Yongjun Fan, Brandon Faubert, Lu Zhao, Jinyu Li, Sarah Neidler, Yu Sun, Nadia Jaber, Dawid Krokowski, Wenyun Lu, Ji-An Pan, Scott Powers, Joshua Rabinowitz, Maria Hatzoglou, Daniel J. Murphy, Russell Jones, Song Wu, Geoffrey Girnun, and Wei-Xing Zong. (2015 Dec) Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation. Cell Metabolism. 22(6):1068-1077. (* contributed equally to this study)
  10. Yu-Ting Hung, Chi-Te Liu, I-Chen Peng, Chin Hsu, Roch-Chui Yu, Kuan-Chen Cheng. (2015 Sep) The implementation of a Hazard Analysis and Critical Control Point management system in a peanut butter ice cream plant. Journal of Food and Drug Analysis. 23(3):509-515.
  11. Brendan Gongol, Traci Marin, I-Chen Peng, Brian Woo, Stephanie King, Marcy Martin, Wei Sun, Shu Chien, and John Y-J. Shyy. (2013). AMPKa2 exerts its anti-inflammatory effects through PARP-1 and Bcl-6. Proc Natl Acad Sci U S A. 110(8):3161-3166.
  12. I-Chen Peng, Kai-Yin Lo, Chun-Hua Hsu, and Chia-Yin Lee. (2012). Increasing the storage and oxidation stabilities of N-acyl-D-amino acid amidohydrolase by site-directed mutagenesis of critical methionine residues. Process Biochemistry. 47:1785-1790.
  13. I-Chen Peng, Zhen Chen, Wei Sun, Ying-Shiuan Li, Traci LaNai Marin, Pang-Hung Hsu, Mei-I Su, Xiaopei Cui, Songqin Pan, Christian Y. Lytle, David A. Johnson, Frank Blaeser, Talal Chatila, and John Y-J. Shyy. (2012). Glucagon regulates ACC activity in adipocytes through the CaMKKb/AMPK pathway. Am J Physiol Endocrinol Metab. 302(12):E1560-1568.
  14. Zhen Chen, I-Chen Peng (co-first author), Xiaopei Cui, Yi-Shuan Li, Shu Chien, and John Y-J. Shyy. (2010). Shear stress, SIRT1, and vascular homeostasis. Proc Natl Acad Sci U S A. 107(22):10268-10273.
  15. Zhen Chen, I-Chen Peng, Wei Sun, Mei-I Su, Pang-Hung Hsu, Yi Fu, Yi Zhu, Kathryn DeFea, Songqin Pan, Ming-Daw Tsai, and John Y-J. Shyy. (2009). AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circ Res. 104:496-505.

 

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